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Categories
» Medical and Health
» Drugs
| NanoCrystal® Technology |
| Country: |
United States of America |
| Link to your website: |
http://www.elan.com/...nology/ |
Description:
NanoCrystal® Technology
For poorly water soluble compounds, Elan's proprietary NanoCrystal technology can enable formulation and improve compound activity and final product characteristics. The NanoCrystal technology can be incorporated into all dosage forms both parenteral and oral, including solid, liquid, fast-melt, pulsed release and controlled release dosage forms.
Poor water solubility correlates with slow dissolution rate, and decreasing particle size increases the surface area, which leads to an increase in dissolution rate. This can be accomplished predictably and efficiently using NanoCrystal technology. NanoCrystal particles are small particles of drug substance, typically less than 1000 nanometers (nm) in diameter, which are produced by milling the drug substance using a proprietary, wet-milling technique. The NanoCrystal particles of the drug are stabilized against agglomeration by surface adsorption of selected GRAS (Generally Regarded As Safe) stabilizers. The result is an aqueous dispersion of the drug substance that behaves like a solution - a NanoCrystal colloidal dispersion, which can be processed into finished dosage forms for all routes of administration. |
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